Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)
نویسندگان
چکیده
This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in deoxyfluorination carboxylic acids to acyl fluorides. The fluorides can be formed from range under mild conditions. We also demonstrate that PFP utilized one-pot amide bond formation via situ generation bond-forming reaction gives ready access amides yields ?94%.
منابع مشابه
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c01953